Higher Order Structure (HOS) Analysis: a Kaleidoscopic Analytical Method Approach to Understanding Structure-Function-Relationships in Biologics
Due to its large size a biopharmaceutical generally exhibits complex three-dimensional higher-order structures (HOS) which are important factors in the protein’s biological function and activity – and thus essential for the therapeutic’s in-vivo efficiency and safety. At the same time they might influence its stability and toxicity. As a consequence, encompassing information on a molecule’s Read more about Higher Order Structure (HOS) Analysis: a Kaleidoscopic Analytical Method Approach to Understanding Structure-Function-Relationships in Biologics[…]